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Neither medication has a clean safety record in isolation

Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)a multicentre, double-blind, randomised, placebo-controlled trial

"Ipamorelin, the first selective growth hormone secretagogue." European Journal of Endocrinology, 1998

However, tirzepatide differs from the other medications in that it is a dual-action GLP-1 (short for glucagon-like peptide 1) and GIP (short for glucose-dependent insulinotropic polypeptide) medication

But mice are not humans, and the research community knew that the real test would come in larger, more complex animals